Intensity modulated radiation therapy (IMRT) treatment planning

This work supported by NSF AGEP and GRF fellowships, NSF DMI grant.

• A response-surface based approach to beam orientation optimization
• Simulated annealing and local search heuristics for beam orientation optimization
• Accounting for fractionation in fluence map optimization in IMRT
• Projected gradient methods applied to fluence map optimization
• Future work:
  • Accounting for inter- and intra-fraction motion
  • Using spatial coefficients in fluence map optimization

Total body irradiation (TBI)

• An optimization approach to TBI
• Using optimization in TBI to bring patients closer to isocenter

Improving the success rate of organ donations

• Using data-mining techniques to more accurately predict the success of organ donations